No verified winning VODs or specific web sources were provided to generate this matchup note. Consequently, the following tips are based on general character knowledge and standard Smash Bros. Ultimate mechanics rather than specific source data. Samus should focus on maintaining distance and utilizing her projectile game to pressure Dedede's approach. Avoiding direct trades is crucial due to Dedede's high damage output and knockback resistance.

• Use Missiles and Charge Shot to control space and punish Dedede's predictable approaches.
• Maintain neutral game by staying at mid-range where Samus has better recovery and projectile options.
• Be cautious of Dedede's strong up-throw and forward smash, which can deal significant damage if they connect.
• Utilize Samus's superior recovery to escape from Dedede's strong grab and throw game.
• Focus on landing safe, low-damage attacks to build meter without risking high-damage trades.
• Watch for Dedede's aerial attacks, as they have high knockback and can lead to quick losses if not avoided.

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